Leinco Technologies

Recombinant Mouse TL1A

Product Code:
 
LEI-T532
Product Group:
 
Recombinant Proteins
Host Type:
 
Mouse
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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LEI-T532-10ug10 ug£614.00
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Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
TL1A, also known as TNFSF15, belongs to the TNF superfamily of ligands. It is expressed predominantly in endothelial cells and to a lesser extent in placenta, lung, kidney, skeletal muscle, pancreas, small intestine and colon. Expression of TL1A is inducible by TNF and IL1-alpha but not by IFN-gamma (1). TL1A can activate NF-κB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells and may function as an angiogenesis inhibitor (2). DcR-3 and DR3 are receptors for membrane-bound and soluble forms of TL1A (1). TL1A also induces secretion of IFN-gamma and GM-CSF. Treatment of T-lymphocytes with TL1A enhances expression of IL-2 receptors and increases proliferation in response to IL-2 (3). Secretion of TL1A in lymphoid organs might contribute to RA initiation by promoting autoantibody production, and TL1A secretion stimulated by inflammatory cytokines in RA joints might be a part of a vicious circle that aggravates RA pathogenesis (4). TL1A may play an important role in a Th1-mediated disease such as Crohn's (5). Treatment of mice with TL1A strongly enhances graft-versus-host reactivity (1).
NCBI Gene:
326623
Purity:
>95% by SDS-PAGE and analyzed by silver stain.
Target:
TL1A

References

1. Migone, TS. et al. (2002) Immunity 16:479 2. Yue, TL. et al. (1999) J. Biol. Chem. 274:1479 3. Papadakis, KA. et al. (2004) J. Immunol. 172:7002 4. Zhang, J. et al. (2009) J. Immunol. 183:5350 5. Bamias, G. et al. (2006) Proc. Natl. Acad. Sci. (USA) 103:8441