Leinco Technologies

Recombinant Human CD22β/Siglec-2

Product Code:
 
LEI-S597
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

No additional charges, what you see is what you pay! *

CodeSizePrice
LEI-S597-50ug50 ug£580.00
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: US.
Typical lead time: 14-21 working days.
Contact us for more accurate information.
  • Further Information
  • References
  • Show All

Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
CD22β, also known as Siglec-2, is a type 1 integral membrane glycoprotein belonging to the Ig family. It is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases. CD22β specifically recognizes sialic acid-containing glycans and is expressed on B cells (1). Both biochemical analysis on various B cells and studies using CD22β-deficient mice have demonstrated that CD22β negatively regulates signaling through the B cell antigen receptor (BCR), which plays a crucial role in response of B cells to antigen stimulation (2). CD22β does this by recruitment and activation of SH2-containing phosphatase 1 (SHP-1), which counteracts the phospharylation-mediated activation of signaling molecules by dephosphorylation, and reduces Ca2+ signaling by regulating the activity of the Ca2+ pump PMCA (3). Unlike other B cell markers, CD22β membrane expression is limited to the late differentiation stages comprised between mature B cells (CD22+) and plasma cells (CD22-), and may thus prove useful in phenotyping mature leukemias (4). CD22β is also strongly expressed in hairy cell leukemia.
NCBI Gene:
933
Purity:
>95% by SDS-PAGE and analyzed by silver stain.
Target:
CD22β

References

1. Sgroi, D. et al. (1993) J. Biol. Chem. 268:7011 2. Poe, JC. et al. (2004) Nature Immunol. 5:1078 3. Tsubata, T. et al. (2001) J. Biol. Chem. 276:26648 4. Van Rossenberg, S. et al. (2001) J. Biol. Chem. 276:12967