Leinco Technologies

Recombinant Mouse IL-12

Product Code:
 
LEI-I-1180
Product Group:
 
Recombinant Proteins
Host Type:
 
Mouse
Regulatory Status:
 
RUO
Shipping:
 
Ambient
 

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CodeSizePrice
LEI-I-1180-10ug10 ug£345.00
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LEI-I-1180-100ug100 ug£1,922.00
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LEI-I-1180-500ug500 ug£5,211.00
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LEI-I-1180-1.0mg1.0 mg£9,819.00
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Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.5 with no calcium, magnesium, or preservatives present.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.5 with no calcium, magnesium, or preservatives present.
Long Description:
IL-12 plays a role in resistance against pathogens via the differentiation of naive T cells into Th1 cells. It stimulates the growth and function of T cells, blocks formation of new blood vessels, and contributes to antimycobacterial immune response. In addition, it promotes the production of IFN-γ and TNF-α and reduces IL-4 mediated suppression of IFN-γ. Consequently, this enhances the immunostimulatory and immunomodulatory effects of IFN-γ. In addition, there appears to be a link between IL-2 and the signal transduction of IL-12 in NK cells, which enhances the functional response of IL-12 via IFN-γ production and killing of target cells. Furthermore, IL-12 is thought to be associated with autoimmunity. IL-12 was shown to worsen the condition when administered to people already suffering from autoimmune diseases. Comparatively, inhibition of IL-12 (either through IL-12 gene knock-out in mice or treatment of mice with IL-12 mAbs) improved the disease.
NCBI Gene:
16159
Purity:
>95% by SDS-PAGE and HPLC
Target:
IL-12

References

1. Kapsenberg, ML. et al. (1997) J. Immunol. 159: 28 2. Ritz, J. et al. (2001) Blood. 97(12):3860-6.3. Barnes, PF. et al. (1994) J Clin Invest. 93(4):1733-9.