Leinco Technologies

Anti-Human CD16 (Clone 3G8) - DyLight® 650

Product Code:
 
LEI-C6857
Product Group:
 
Primary Antibodies
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1 κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
3G8
Regulatory Status:
 
RUO
Target Species:
  • Baboon
  • Chimpanzee
  • Cynomolgus Monkey
  • Human
  • Marmoset
  • Pigtailed macaque
  • Rhesus Macaque
  • Squirrel monkey
Application:
 
Flow Cytometry
Shipping:
 
2-8°C
Storage:
 
This DyLight® 650 conjugate is stable when stored at 2-8°C. Do not freeze.
 

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LEI-C6857-100ug100 ug£263.00
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Further Information

Antigen Distribution:
CD16 is expressed on NK cells, activated monocytes, macrophages, neutrophils, and placental trophoblasts.
Concentration:
0.2 mg/ml
Conjugate/Tag/Label:
DyLight® 650
Format:
This DyLight® 650 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Formulation:
This DyLight® 650 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Immunogen:
Human PMN cells
Long Description:
CD16 antibody, 3G8, recognizes human CD16, also known as low-affinity IgG receptor III (FcγRIII). There are two distinct forms of CD16, CD16a (FcγRIIIa) and CD16b (FcγRIIIb). CD16a is a 50-65 kDa heterooligomeric polypeptide-anchored transmembrane protein expressed by NK cells, macrophages, and subsets of monocytes1. CD16b is a 48 kDa monomeric glycosylphosphatidylinositol (GPI)-anchored protein expressed on neutrophils1. Upon binding to the Fc portion of IgG or IgG-antigen complex, both CD16 isoforms induce signaling cascades resulting in multiple functions, including phagocytosis, cytokine release, proliferation, degranulation, and antibody dependent cell-mediated cytotoxicity (ADCC)2.
NCBI Gene:
2214
Target:
CD16

References

1. Ravetch JV & Perussia B. (1989) J Exp Med. 170(2):481-497 2. Nimmerjahn F & Ravetch JV (2008) Nat Rev Immunol. 8(1):34-47