Leinco Technologies

Anti-Human TCR Vα24-Jα18 (iNKT cell)- Purified

Product Code:
 
LEI-T1706
Product Group:
 
Primary Antibodies
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1 κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
6B11
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Shipping:
 
2-8°C
Storage:
 
This purified antibody is stable when stored at 2-8°C. Do not freeze.
 

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CodeSizePrice
LEI-T1706-100ug100 ug£179.00
Quantity:
LEI-T1706-500ug500 ug£439.00
Quantity:
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Further Information

Antigen Distribution:
The Vα24-Jα18 TCR is expressed on iNKT cells.
Concentration:
0.5 mg/ml
Conjugate/Tag/Label:
Purified
Format:
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Formulation:
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Long Description:
TCR Vα24-Jα18 antibody, 6B11, recognizes the CDR3 region of the V alpha 24 and J alpha 18 TCR alpha locus (Vα24-Jα18). The Vα24-Jα18 semi-invariant TCR is expressed on a highly conserved T cell subset, named invariant natural killer T (iNKT cells), which also express NK cell-associated molecules. The Vα24-Jα18 TCR recognizes lipid antigens, such as α-galactosylceramide (α-GalCer), presented by the MHC class I-like molecule CD1d1. Following activation, iNKT cells rapidly proliferate and produce large amounts of IL-4, IFNγ, and cytolytic mediators2,3. iNKT cells have both inflammatory and immunoregulatory functions and are implicated in anti-tumor immunity, protection against infections, suppression of autoimmunity, and the development of inflammatory diseases4.
NCBI Gene:
28659
Target:
TCR Vα24-Jα18

References

1. Van Kaer L., et al. (2004) Nat Rev Immunol. 4(3):231-7 2. Teyton L., et al. (2006) Annu Rev Immunol. 25:297?336 3. Kronenberg M. (2004) Annu Rev Immunol. 23:877?900 4. Van Kaer L & Wu L. (2018) Front Immunol. 9:519