CircuLex S100P ELISA Kit
Product Code:
MBL-CY-8060
MBL-CY-8060
Regulatory Status:
RUO
RUO
Application:
Enzyme-Linked Immunosorbent Assay (ELISA)
Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
4°C
4°C
Storage:
4°C
4°C
No additional charges, what you see is what you pay! *
| Code | Size | Price |
|---|
| MBL-CY-8060 | 96 Assays | £602.00 |
Quantity:
Prices exclude any Taxes / VAT
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
- Further Information
- Documents
- References
- Show All
Further Information
Background:
Members of the S100 protein family are low molecular mass acidic proteins characterized by
cell-type-specific expression and the presence of 2 EF-hand calcium-binding domains. One of the least
studied members of the S100 family is S100P, a 95-amino acid protein first purified from placenta with a
restricted cellular distribution (1, 2). The molecular structure of S100P has been well described and
supports its classification in the S100 family of proteins (3). Expression of S100P has been noted in
esophageal epithelial cells during their differentiation, indicating that it may play a role in normal
development (4). There is also considerable evidence that S100P plays a role in cancer. S100P
expression has been noted in various cancer cell lines including breast cancer, where it was associated
with cellular immortalization (5), and colon cancer, where its expression was elevated in
doxorubicin-resistant cells (6). S100P has also been shown to be expressed in tumors, including prostate
cancer, where its expression is androgen-sensitive (7), and pancreatic adenocarcinoma, where expression
has been localized to the neoplastic epithelium of pancreatic (8). Furthermore, S100P expression has
been shown to be correlated with decreased survival in patients with lung cancer (9).
Description:
The CircuLex™ S100P ELISA kit is used for the quantitative measurement of S100P in cell lysate,
cell culture conditioned medium, serum, plasma and other biological media.
Gene IDs:
Human: 6286 Mouse: 74648
Kit Components:
Microplate, 10X Wash Buffer, Dilution Buffer, Human S100P Standard, HRP conjugated Detection Antibody, Substrate Reagent, Stop Solution
Measurement Range:
Results exceeding S100P level of 5 ng/ml should be repeated with diluted samples. Dilution factors need
to be taken into consideration in calculating the S100P concentration.
Sensitivity:
better than 0.2 ng/ml of sample.
Target:
S100P
Documents
References
1. Becker, T., Gerke, V., Kube, E., and Weber, K. (1992) Eur. J. Biochem. 207, 541?547
2. Emoto, Y., Kobayashi, R., Akatsuka, H., and Hidaka, H. (1992) Biochem. Biophys. Res. Commun. 182,
1246?1253
3. Zhang, H., Wang, G., Ding, Y., Wang, Z., Barraclough, R., Rudland, P. S., Fernig, D. G., and Rao, Z.
(2003) J. Mol. Biol. 325, 785?794
4. Sato, N., and Hitomi, J. (2002) Anat. Rec. 267, 60?69
5. Guerreiro, D. S., I, Hu, Y. F., Russo, I. H., Ao, X., Salicioni, A. M., Yang, X., and Russo, J. (2000) Int.
J. Oncol. 16, 231?240
6. Bertram, J., Palfner, K., Hiddemann, W., and Kneba, M. (1998) Anticancer Drugs 9, 311?317
7. Averboukh, L., Liang, P., Kantoff, P. W., and Pardee, A. B. (1996) Prostate 29, 350?355
8. Logsdon, C. D., Simeone, D. M., Binkley, C., Arumugam, T., Greenson, J. K., Giordano, T. J., Misek,
D. E., and Hanash, S. (2003) Cancer Res. 63, 2649?2657
9. Beer, D. G., Kardia, S. L., Huang, C. C., Giordano, T. J., Levin, A. M., Misek, D. E., Lin, L., Chen, G.,
Gharib, T. G., Thomas, D. G., Lizyness, M. L., Kuick, R., Hayasaka, S., Taylor, J. M., Iannettoni, M.
D., Orringer, M. B., and Hanash, S. (2002) Nat. Med. 8, 816?824