NAMPT (Human, Active)

Nicotinamide phosphoribosyltransferase, pre-B-cell colony-enhancing factor 1, PBEF, Visfatin

Nicotinamide phosphoribosyltransferase (NAMPT), also known as pre-B-cell colony-enhancing factor, is the rate-limiting enzyme that converts nicotinamide to nicotinamide mononucleotide (NMN) from nicotinamide in the salvage pathway of NAD biosynthesis in mammals. Nicotinamide mononucleotide adenylyltransferase 1 converts NMN to NAD. The expression of NAMPT is upregulated during activation of immune cells such as monocytes, macrophages, dendritic cells, T and B cells, as well as in amniotic epithelial cells upon stimulation with several inflammatory cytokines. NAMPT-specific inhibitor, FK866 was found to deplete intracellular NAD content, resulting in apoptotic cell death in many cancer cell lines without any DNA damaging effect.

1.0 ug/ul

Human NAMPT (nicotinamide phosphoribosyltransferase) containing an N-terminal His-tag, expressed in E. coil. and purified by nickel chelating agarose chromatography.

Recombinant NAMPT is supplied frozen in a buffer containing 20 mM Hepes-KOH, pH 7.5, 1 mM DTT, 50 mM NaCl and 50% glycerol. Use a same buffer for dilution when needed.

The gene/protein accession number is NM_005746

Human: 10135 Mouse: 59027

56 kDa

1 year

NAMPT