CircuLex LDLR EGF-AB domain
Product Code:
MBL-CY-R2340
MBL-CY-R2340
Regulatory Status:
RUO
RUO
Shipping:
Dry Ice
Dry Ice
Storage:
-70°C
-70°C
No additional charges, what you see is what you pay! *
Code | Size | Price |
---|
MBL-CY-R2340 | 50 ug | £637.00 |
Quantity:
Prices exclude any Taxes / VAT
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
- Further Information
- Documents
- References
- Show All
Further Information
Background:
PCSK9 binds to the LDL receptor in vitro though LDLR EGF-A domain. Human
LDLR EGF-AB domain is expressed in E.coli. and purified by and GSH-column- and ion
exchange-chromatography. Binding capability of the LDLR EGF-AB domain to recombinant PCSK9
was confirmed by using CircuLex PCSK9-LDLR in vitro Binding Assay Kit (Cat# CY-8150).
Concentration:
500 ug/mL
Formulation:
The LDLR EGF-AB domain is supplied frozen in 20 mM sodium phosphate buffer pH
7.2, 290 mM NaCl and 10 % glycerol.
Gene IDs:
Human: 3949 Mouse: 16835
MW:
The LDLR EGF-AB domain demonstrates ~15 kDa by SDS-PAGE analysis.
Purity:
The LDLR EGF-AB domain is greater than 90 % pure as determined by SDS-PAGE analysis.
Shelf Life:
1 year
Source:
Human LDLR EGF-AB domain, expressed in E. coli.
Target:
LDLR EGF
Documents
References
1. Seidah NG, Benjannet S, Wickham L, Marcinkiewicz J, Jasmin SB, Stifani S, Basak A, Prat A,
Chretien M (2003) Proc Natl Acad Sci USA 100:928?933.
2. Abifadel M, Varret M, Rabes JP, Allard D, Ouguerram K, Devillers M, Cruaud C, Benjannet S,
Wickham L, Erlich D, et al. (2003) Nat Genet 34:154?156.
3. Leren TP (2004) Clin Genet 65:419?422.
4. Allard D, Amsellem S, Abifadel M, Trillard M, Devillers M, Luc G, Krempf M, Reznik Y, Girardet JP,
Fredenrich A, et al. (2005) Hum Mutat 26:497.
5. Cohen JC, Boerwinkle E, Mosley TH, Jr, Hobbs HH (2006) N Engl J Med 354, 1264?1272.
6. Berge KE, Ose L, Leren TP (2006) Arterioscler Thromb Vasc Biol 26:1094?1100.
7. Maxwell KN, Breslow JL (2004) Proc Natl Acad Sci USA 101:7100?7105.
8. Rashid S, Curtis DE, Garuti R, Anderson NN, Bashmakov Y, Ho YK, Hammer RE, Moon YA, Horton
JD (2005) Proc Natl Acad Sci USA 102:5374?5379.
9. Lagace, T. A., Curtis, D. E., Garuti, R., McNutt, M. C., Park, S. W., Prather, H. B., Anderson, N. N.,
Ho, Y. K., Hammer, R. E., and Horton, J. D. (2006) J. Clin. Investig. 116, 2995?3005
10. Cameron, J., Holla, O. L., Ranheim, T., Kulseth, M. A., Berge, K. E., and Leren, T. P. (2006) Hum.
Mol. Genet. 15, 1551?1558
11. Zhang, D. W., Lagace, T. A., Garuti, R., Zhao, Z., McDonald, M., Horton, J. D., Cohen, J. C., and
Hobbs, H. H. (2007) J. Biol. Chem. 282, 18602?18612
12. Hyock Joo Kwon*, Thomas A. Lagace?, Markey C. McNutt?, Jay D. Horton??, and Johann
Deisenhofer (2008) ) Proc Natl Acad Sci USA 105: 1820?1825.
13. Matthew J. Bottomley et al. (2009) J. Biol. Chem., Jan 2009; 284: 1313-1323.
14. McNutt MC, Kwon HJ, Chen C, Chen JR, Horton JD, Lagace TA. (2009) J Biol Chem. 2009 Feb 17.