MBL

Anti-Glypican 1 (Human) mAb

Product Code:
 
MBL-W253-3
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Mouse
Antibody Isotype:
 
IgG2a κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
12C1E2F
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Shipping:
 
4°C
Storage:
 
-20°C
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MBL-W253-3100 ul£323.00
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  • Further Information
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Further Information

Applications:
FCM - 1-10 ug/mL
Background:
Glypican 1 (GPC1) is a member of cell surface heparan sulfate proteoglycan family. GPC1 is a GPI-anchored type membrane protein and probably involves in the control of cell division and growth regulation. GPC1 also associates with fibrillar APP A-beta peptides in lipid rafts in Alzheimer disease brains. In pancreatic ductal adenocarcinoma, enhanced GPC1 expression is suggested to correlate with BMP and activin receptors. Down-regulation of GPC1 results in suppression of pancreatic cancer cell growth.
Formulation:
1 mg/mL in PBS/50% glycerol, pH 7.2
Gene IDs:
Human: 2817
Immunogen Translated:
Human Glypican 1 expressed Ba/F3transfectants generated from SST-REX (signal sequence trap by retrovirus-mediated expression screening).
Reactivity:
This antibody reacts with human Glypican 1 on Flow cytometry
Source:
This antibody was purified from hybridoma culture supernatant by Protein A affinity column chromatography.
Target:
Glypican 1

Documents

References

1) Cheng, F., et al., J. Biol. Chem. 286, 27559-27572 (2011) 2) Svensson, G. and Mani, K., Glycoconj. J. 26, 1247-1257 (2009) 3) Mani, K., et al., Glycobiology 16, 1251-1261 (2006) 4) Watanabe, N., et al., FASEB J. 18, 1013-1015 (2004) 5) Kojima, T and Kitamura, T. Nat. Biotechnol. 17, 487-490 (1999) 6) Vermeesch, S. A., et al., Genomics 25, 327-329 (1995) 7) David, G., et al., J. Cell Biol. 111, 3165-3176 (1990)