MBL

Anti-CD70 (Mouse) mAb Functional Grade

Product Code:
 
MBL-FP20042550
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Rat
Antibody Isotype:
 
IgG2b κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
FR70
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Flow Cytometry
  • Functional Study
Shipping:
 
4°C
Storage:
 
4°C
 

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MBL-FP20042550500 ug£603.00
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Further Information

Background:
The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily. CD70 is the ligand for CD27 and is expressed on dendritic cells, activated B cell, and a subset of activated T cells at lower levels. Its main role is in regulating B cell activation and immunoglobulin synthesis. CD70 expressing cells are able to co-stimulate T cell proliferation and upregulate cytokine production. The FR70 antibody is reported to block the binding of CD70 to CD27.
Concentration:
1 mg/mL
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
Target:
CD70

Documents

References

Akashi, S., et al., J Exp Med. 198, 1035-1042 (2003) Qi, H. Y., & Shelhamer, J. H., J. Biol. Chem. 280, 38969-38975 (2005) Shimazu, R., et al., J Exp Med. 189, 1777-1782 (1999)