Elabscience

Recombinant Human PFKFB3 (N-6His)

Product Code:
 
PKSH033971
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt store it immediately at < -20°C.
Storage:
 
Store at < -20°C stable for 6 months after receipt. Please minimize freeze-thaw cycles.
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CodeSizePrice
PKSH033971-10ug10ug£239.00
Quantity:
PKSH033971-50ug50ug£560.00
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Further Information

Abbreviation:
PFKFB3
Accession:
Q16875
Background:
Fructose-2,6-biphosphatase 3, also known as 6-phosphofructo-2-kinase or PFK2 or PFKFB3, involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls the activity of the enzymes phosphofructokinase 1 (PFK-1) and fructose 1,6-bisphosphatase (FBPase-1) to regulate glycolysis and gluconeogenesis. Highly phosphorylated PFKFB3 protein was found in human tumor cells, vascular endothelial cells, and smooth muscle cells. Because of its proto-oncogenic character, the PFK-2/FBPase-2 of the PFKFB3 gene is assumed to play a critical role in tumorigenesis. PFKFB3 also plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways even under severe hypoxic conditions, which makes it a potential target for cancer therapy.
Calculated MW:
61.8 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
E.coli
Formulation:
Supplied as a 0.2 um filtered solution of 50mM Tris-HCl, 50mM KCl, 1mM DTT, 0.1mM EDTA, 20% Glycerol, pH 8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
N-6His
ObservedMW:
57-62 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Met1-His520
Target Synonym:
IPFK2;PFK2;iPFK-2;PFK/FBPase 3
UNIProt ID:
Q16875

Documents