Elabscience

Recombinant Cynomolgus Interleukin-17A/IL-17A (C-6His)

Product Code:
 
PKSQ050109
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Monkey
Regulatory Status:
 
RUO
Application:
 
Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Immobilized Cynomolgus IL-17A-His (Cat#PKSQ050109) at 10 ug/ml (100 ul/well) can bind Anti-Human IL-17A mAb. The ED50 of Anti-Human IL-17A mAb is 128 ng/ml.
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Immobilized Cynomolgus IL-17A-His (Cat#PKSQ050109) at 10 ug/ml (100 ul/well) can bind Anti-Human IL-17A mAb. The ED50 of Anti-Human IL-17A mAb is 128 ng/ml.

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CodeSizePrice
PKSQ050109-10ug10ug£225.00
Quantity:
PKSQ050109-50ug50ug£521.00
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This product comes from: China.
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Further Information

Abbreviation:
Interleukin-17A;IL-17A
Accession:
G7P4U9
Activity:
Immobilized Cynomolgus IL-17A-His (Cat#PKSQ050109) at 10 ug/ml (100 ul/well) can bind Anti-Human IL-17A mAb. The ED50 of Anti-Human IL-17A mAb is 128 ng/ml.
Background:
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.
Calculated MW:
15.9 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-6His
ObservedMW:
15-25 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Gly24-Ala155
Target Synonym:
Interleukin-17A;IL-17;IL-17A;Cytotoxic T-Lymphocyte-Associated Antigen 8;CTLA-8;IL17A;CTLA8;IL17
UNIProt ID:
G7P4U9

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