Elabscience

Recombinant Human FcRn & B2M Heterodimer (C-6His-Avi) Biotinylated

Product Code:
 
PKSH033906
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Application:
 
Bio-Layer Interferometry
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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CodeSizePrice
PKSH033906-20ug20ug£351.00
Quantity:
PKSH033906-100ug100ug£819.00
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This product comes from: China.
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Further Information

Abbreviation:
FcRn;B2M
Accession:
AAF72596&P61769
Activity:
Loaded Biotinylated Human FcRn Heterodimer-His-Avi on HIS1K Biosensor, can bind Anti-Human HER2 mAb with an affinity constant of 0.11 uM as determined in BLI assay.
Background:
FcRn complex consist of two subunits: IgG receptor FcRn large subunit p51 (alpha chain) and Beta-2-microglobulin (Beta chain). The complexes is similar in structure to MHC class I-like heterodimer. Beta-2-microglobulin involved in the presentation of peptide antigens to the immune system. FcRn binds to the Fc region of monomeric immunoglobulins gamma, mediates the uptake of IgG from milk,Possible role in transfer of immunoglobulin G from mother to fetus. A principal component of antibody transport is the neonatal receptor for the Fc portion of immunoglobulin, a heterodimer of a MHC-1 alpha-chain homolog ( FcRn ) and beta-2-microglobulin ( B2M ).
Calculated MW:
31.1&13.5 kDa
Conjugation:
Biotinylated
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of 20mM PB, 6% Sucrose, 4% Mannitol, 0.05% Tween 80, pH 7.8.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-6His-Avi
ObservedMW:
35&13 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Ala24-Ser297&Ile21-Met119
Target Synonym:
IgG receptor FcRn;Neonatal Fc receptor;FCRN

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