Elabscience

Recombinant Human B-cell Receptor CD22/Siglec-2/CD22 (C-6His) Biotinylated

Product Code:
 
PKSH033956
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Application:
 
Bio-Layer Interferometry
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Loaded Biotinylated Human Siglec-2-His-Avi on HIS1K Biosensor, can bind Anti-Human Siglec-2 mAb-Fc with an affinity constant of 0.16 nM as determined in BLI assay.
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Loaded Biotinylated Human Siglec-2-His-Avi on HIS1K Biosensor, can bind Anti-Human Siglec-2 mAb-Fc with an affinity constant of 0.16 nM as determined in BLI assay.

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PKSH033956-20ug20ug£351.00
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PKSH033956-100ug100ug£819.00
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Further Information

Abbreviation:
Siglec-2;CD22
Accession:
P20273
Activity:
Loaded Biotinylated Human Siglec-2-His-Avi on HIS1K Biosensor, can bind Anti-Human Siglec-2 mAb-Fc with an affinity constant of 0.16 nM as determined in BLI assay.
Background:
Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Human Siglec-2, also known as B-cell antigen CD22 or B-lymphocyte cell adhesion molecule (BL-CAM), is a B-cell restricted glycoprotein that is expressed in the cytoplasm of progenitor B and pre-B cells and on the surface of mature B cells. Two distinct human Siglec-2/CD22 cDNAs that arise from differential RNA processing of the same gene have been isolated. Siglec-2/CD22 is an adhesion molecule that preferentially binds alpha 2,6- linked sialic acid on the same (cis) or adjacent (trans) cells. Interaction of CD22 with trans ligands on opposing cells was found to be favored over the binding of ligands in cis.
Calculated MW:
78 kDa
Conjugation:
Biotinylated
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-6His-Avi
ObservedMW:
110-130 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Asp20-Arg687
Target Synonym:
B-cell receptor CD22;BL-CAM;B-lymphocyte cell adhesion molecule;CD22 antigenMGC130020;CD22 molecule;CD22;sialic acid binding Ig-like lectin 2;Siglec-2;SIGLEC2FLJ22814;T-cell surface antigen Leu-14
UNIProt ID:
P20273

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