Elabscience

MAP2K3 Polyclonal Antibody

Product Code:
 
E-AB-67908
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Immunohistochemistry of paraffin-embedded Human colon carcinoma using MAP2K3 Polyclonal Antibody at dilution of 1:100 (40x lens).
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Immunofluorescence analysis of U-2 OS cells using MAP2K3 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
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Immunohistochemistry of paraffin-embedded Human colon carcinoma using MAP2K3 Polyclonal Antibody at dilution of 1:100 (40x lens).
Immunofluorescence analysis of U-2 OS cells using MAP2K3 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.

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E-AB-67908-60uL60uL£210.00
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E-AB-67908-120uL120uL£291.00
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E-AB-67908-200uL200uL£431.00
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Further Information

Abbreviation:
MAP2K3
Background:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200 IF 1:50-1:200
Immunogen:
Recombinant fusion protein of human MAP2K3 (NP_659731.1).
Purification method:
Affinity purification
Target Synonym:
MAP2K3;MAPKK3;MEK3;MKK3;PRKMK3;SAPKK-2;SAPKK2
UNIProt ID:
P46734

Documents