Elabscience

Recombinant Cynomolgus TIM-3/HAVCR2 Protein (Fc Tag)

Product Code:
 
PKSQ050022
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Monkey
Regulatory Status:
 
RUO
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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CodeSizePrice
PKSQ050022-10ug10ug£170.00
Quantity:
PKSQ050022-50ug50ug£315.00
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This product comes from: China.
Typical lead time: 14-21 working days.
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Further Information

Abbreviation:
TIM-3;HAVCR2
Accession:
G7P6Q7
Background:
T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. TIM3 interactions with Galectin-9 can trigger immune stimulatory effects, such as the coactivation of NK cell cytotoxicity.
Calculated MW:
46.3 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-Fc
ObservedMW:
55-75 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Ser22-Arg201
Target Synonym:
T cell immunoglobulin and mucin domain3;HAVCR2;Tim-3;TIM3
UNIProt ID:
G7P6Q7

Documents