Elabscience

Recombinant Mouse ICOS/AILIM Protein (His Tag)

Product Code:
 
PKSM041217
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Mouse
Regulatory Status:
 
RUO
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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CodeSizePrice
PKSM041217-10ug10ug£106.00
Quantity:
PKSM041217-50ug50ug£166.00
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This product comes from: China.
Typical lead time: 14-21 working days.
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Further Information

Abbreviation:
ICOS;AILIM
Accession:
Q9WVS0
Background:
Inducible Costimulator(ICOS) is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA4 and PD1. ICOS shares approximately 39% amino acid similarity with CD 28 and CTLA4. Mouse and human ICOS share approximately 72% amino acid identity. ICOS is expressed on most CD45RO+ cells. ICOS expression is up-regulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation. In addition, ICOS is more potent in the induction of IL-10 production, acytokine important for suppressive function of T regulatory cells.
Calculated MW:
14.7 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-6His
ObservedMW:
16-30 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Glu21-Leu142
Target Synonym:
Inducible T-cell costimulator;Activation-inducible lymphocyte immunomediatory molecule;CD28 and CTLA-4-like protein;CCLP;CD28-related protein 1;CRP-1;CD278;Icos;Ailim;AILIM;CCLP;CRP-1;H4;Ly115
UNIProt ID:
Q9WVS0

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