Elabscience

Recombinant Human TIGIT Protein (Fc Tag)

Product Code:
 
PKSH033510
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
 

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CodeSizePrice
PKSH033510-10ug10ug£219.00
Quantity:
PKSH033510-50ug50ug£497.00
Quantity:
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This product comes from: China.
Typical lead time: 14-21 working days.
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Further Information

Abbreviation:
TIGIT
Accession:
Q495A1
Background:
T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the CD28 family within the Ig superfamily of proteins. TIGIT is expressed on NK cells and subsets of activated; memory and regulatory T cells; and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155 and Nectin-2 that appear on dendritic cells (DC) and endothelium. Ligation of TIGIT on T cells down-regulates TCR-mediated activation and subsequent proliferation; while NK cell TIGIT ligation blocks NK cell cytotoxicity. Through CD155 and Nectin-2; which also interact with DNAM-1/CD226 and CD96/Tactile; TIGIT is part of an interacting network of Ig superfamily members that may augment or oppose each other. In particular; TIGIT binding to CD155 can antagonize the effects of DNAM1.
Calculated MW:
39.7 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-Fc
ObservedMW:
40-55 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Met22-Pro141
Target Synonym:
T-cell immunoreceptor with Ig and ITIM domains;V-set and immunoglobulin domain-containing protein 9;V-set and transmembrane domain-containing protein 3;Tigit;VSIG9;VSTM3
UNIProt ID:
Q495A1

Documents