Elabscience

ASC / TMS1 Polyclonal Antibody

Product Code:
 
E-AB-60228
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunofluorescence (IF)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Western blot analysis of extracts of various cell lines using ASC / TMS1 Polyclonal Antibody.
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Immunofluorescence analysis of HeLa cells using ASC / TMS1 Polyclonal Antibody
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Western blot analysis of extracts of various cell lines using ASC / TMS1 Polyclonal Antibody.
Immunofluorescence analysis of HeLa cells using ASC / TMS1 Polyclonal Antibody

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E-AB-60228-60uL60uL£210.00
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E-AB-60228-120uL120uL£291.00
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E-AB-60228-200uL200uL£431.00
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  • Further Information
  • Documents
  • References
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Further Information

Abbreviation:
ASC / TMS1
Background:
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Calculated MW:
15kDa/19kDa/21kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000 IF 1:50-1:200
Immunogen:
Recombinant fusion protein of human ASC / TMS1 (NP_037390.2).
ObservedMW:
22kDa
Purification method:
Affinity purification
Target Synonym:
PYCARD;ASC;CARD5;TMS;TMS-1;TMS1;PYD and CARD domain containing;ASC / TMS1
UNIProt ID:
Q9ULZ3

Documents

References

  • https://www.sciencedirect.com/science/article/pii/S1567576923002242
  • https://www.nature.com/articles/s41598-022-04785-z
  • https://journals.lww.com/neuroreport/Fulltext/2021/06020/Protective_effects_of_melatonin_on_the_white.1.aspx?context=LatestArticles