Recombinant Mouse IL1RL1/ST2 Protein (Fc Tag) (Active)

IL1RL1;ST2

P14719-2

Immobilized Mouse IL-33(Cat: PKSM041090) at 5ug/ml(100 ul/well) can bind Mouse ST2-Fc. The ED50 of Mouse ST2-Fc is 5ug/ml.

ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes. This receptor is very similar to the IL-1 receptor type I and the IL-18 receptor α chain in that ST2 also has three extracellular Ig domains and an intracellular Toll domain. ST2 binds IL-33, enhances inflammatory cytokines by activating nuclear factor-κB (NF-κB) and mitogen activated protein (MAP) kinases. ST2 exists as either a membrane bound form (ST2L) or as a soluble form (sST2). ST2L acts as a transmembrane signalling receptor for IL-33 by mediating the effect of IL-33 on the inflammatory process, while sST2 can suppress IL-33 activity.

62.7 kDa

< 1.0 EU per ug of the protein as determined by the LAL method.

HEK293 Cells

Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

C-Fc

90-110 kDa

> 95 % as determined by reducing SDS-PAGE.

Ser27-Ala337

Interleukin-1 receptor-like 1;Lymphocyte antigen 84;Protein ST2;Protein T1;Il1rl1;DER4;Fit-1;IL-1 R4;IL-1RL1;IL-33R;Ly84;ST2L;ST2V;suppression of tumorigenicity 2

P14719