Elabscience

Recombinant Mouse IL-1 beta/IL1B Protein (Active)

Product Code:
 
PKSM040957
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Mouse
Regulatory Status:
 
RUO
Application:
 
Cell Culture
Shipping:
 
The product is shipped at ambient temperature. Upon receipt store it immediately at the storage temperature listed.
Storage:
 
Store at < -20°C stable for 6 months after receipt. Please minimize freeze-thaw cycles.
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CodeSizePrice
PKSM040957-20ug20ug£210.00
Quantity:
PKSM040957-100ug100ug£472.00
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Further Information

Abbreviation:
IL-1 beta;IL1B
Accession:
P10749
Activity:
Measure by its ability to induce D10.G4. 1 cells proliferation. The ED50 for this effectis < 8 pg/mL. The specific activity of recombinant mouse IL-1 beta is approximately > 1. 2x 108lU/mg.
Background:
Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).
Calculated MW:
17.5 kDa
Endotoxin:
< 0.01 EU per ug of the protein as determined by the LAL method.
Expression Host:
E.coli
Formulation:
Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-His
ObservedMW:
19 kDa
Purity:
> 98 % as determined by reducing SDS-PAGE.
Sequence:
Val 118-Ser 269
Target Synonym:
Il-1b;IL-1beta
UNIProt ID:
P10749

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