Elabscience

Recombinant Human SerpinA1/A1AT Protein (His Tag)

Product Code:
 
PKSH033030
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Samples are stable for up to twelve months from date of receipt at -70°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
 

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CodeSizePrice
PKSH033030-10ug10ug£219.00
Quantity:
PKSH033030-50ug50ug£497.00
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This product comes from: China.
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Further Information

Abbreviation:
SerpinA1;A1AT
Accession:
AAH11991.1
Background:
Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors. As one of the most abundant proteinase inhibitors in the circulation, it is synthesized in hepatocytes, and to a lesser extent, in macrophages as well as intestinal epithelial cell lines and secreted as the abundant proteinase inhibitor in the circulation whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Point mutations in the native SerpinA1 variants result in Serpin A1 deficiency, and consequently lead to several clinical complications such as pulmonary emphysema, juvenile hepatitis, cirrhosis, and hepatocellular carcinoma. For example, the Z variants (Glu342 to Lys) forms intracellular inclusion bodies, is not secreted, and leads to a severe SerpinA1 deficiency. Accordingly, Serpin A1 deficiency in circulation is associated with emphysema or liver disease.
Calculated MW:
45.4 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of 20mM Tris-HCl, 150mM NaCl, 2mM CaCl2, pH 7.5.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-6His
ObservedMW:
50-65 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Glu25-Lys418
Target Synonym:
Alpha-1-Antitrypsin;Alpha-1 Protease Inhibitor;Alpha-1-Antiproteinase;Serpin A1;SERPINA1;AAT;PI;A1A;A1AT;AAT;alpha1AT;MGC23330;MGC9222;PI1;PRO2275

Documents