Elabscience

Recombinant Human R-Spondin 1/RSPO1 Protein (aa 1-146, His Tag)(Active)

Product Code:
 
PKSH031268
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Application:
 
Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Samples are stable for up to twelve months from date of receipt at -70°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
 

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CodeSizePrice
PKSH031268-100ug100ug£742.00
Quantity:
PKSH031268-1mg1mg£4,398.00
Quantity:
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This product comes from: China.
Typical lead time: 14-21 working days.
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Further Information

Abbreviation:
R-Spondin 1;RSPO1
Accession:
NP_001033722.1
Activity:
Measured by its ability to bind recombinant mouse CD36 in a functional ELISA.
Background:
RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO1 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. It also acts as a ligand for frizzled FZD8 and LRP6.
Calculated MW:
14 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-His
ObservedMW:
23 kDa
Purity:
> 98 % as determined by reducing SDS-PAGE.
Sequence:
Met 1-Ala 146
Target Synonym:
RSPO1;R-spondin1;RP11-566C13.1;CRISTIN3;FLJ40906;RSPO Rspo1;R-spondin;Rspondin;RP23-325M14.2;Roof plate-specific spondin-1

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