Recombinant Human MMP1 Protein (His Tag)
Shipping:
The product is shipped at ambient temperature. Upon receipt store it immediately at the storage temperature listed.
Storage:
Lyophilized protein should be stored at < -20°C though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months
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This product comes from:
China.
Typical lead time:
14-21 working days.
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Further Information
MMP1
P03956
Matrix Metalloproteinase-1 (MMP-1) is expressed by fibroblasts, keratinocytes, endothelial cells, monocytes and macrophages. MMP1 contains several distinct domains: a prodomain that is cleaved upon activation, a catalytic domain containing the zinc binding site, a short hinge region, and a carboxyl terminal (hemopexin like) domain. MMP-1 can degrade a broad range of substrates including types I, II, III, VII, VIII, and X collagens as well as casein, gelatin, α1 antitrypsin, myelin basic protein, L-Selectin, pro-TNF, IL1, IGFBP3, IGFBP5, pro-MMP2, and pro-MMP9. A significant role of MMP1 is the degradation of fibrillar collagens in extracellular matrix remodeling, characterized by the cleavage of the interstitial collagen triple helix into 3/4, 1/4 fragments. MMP1 may also be involved in enzyme cascades, cytokine regulation and cell surface molecule modulation.
52.88 kDa
< 1.0 EU per ug of the protein as determined by the LAL method.
HEK293 Cells
Supplied as a 0.2 um filtered solution of 20mM MES, 150mM NaCl, 0.05% Brij35, pH 5.5.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
C-6His
56 kDa
> 95 % as determined by reducing SDS-PAGE.
Phe20-Asn469
Interstitial Collagenase;Fibroblast Collagenase;Matrix Metalloproteinase-1;MMP-1;MMP1;CLG
P03956
