Elabscience

Recombinant Human IDE/Insulysin Protein (His Tag)

Product Code:
 
PKSH032593
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage:
 
Lyophilized protein should be stored at < -20°C though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months
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CodeSizePrice
PKSH032593-10ug10ug£256.00
Quantity:
PKSH032593-50ug50ug£553.00
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This product comes from: China.
Typical lead time: 14-21 working days.
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Further Information

Abbreviation:
IDE;Insulysin
Accession:
P14735
Background:
Insulin-Degrading Enzyme (IDE) is a secreted enzyme that belongs to the peptidase M16 family. IDE is a large zinc-binding protease and cleaves multiple short polypeptides that vary considerably in sequence. IDE plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling. IDE degrades amyloid formed by APP and IAPP. IDE may participate in the degradation and clearance of naturally secreted amyloid β-protein by neurons and microglia. IDE, which migrates at 110 kDa during gel electrophoresis under denaturing conditions, has since been shown to have additional substrates, including the signaling peptides glucagon, TGF α and β-endorphin.
Calculated MW:
114.3 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Supplied as a 0.2 um filtered solution of 20mM Tris-HCl,150mM NaCl,0.05%Brij35,10% Glycerol,pH7.5.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-6His
ObservedMW:
120 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Met42-Leu1019
Target Synonym:
Insulin-Degrading Enzyme;Abeta-Degrading Protease;Insulin Protease;Insulinase;Insulysin;IDE
UNIProt ID:
P14735

Documents