Elabscience

Recombinant Human IDO1/IDO Protein (His Tag)(Active)

Product Code:
 
PKSH032584
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage:
 
Lyophilized protein should be stored at < -20°C though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months
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CodeSizePrice
PKSH032584-10ug10ug£256.00
Quantity:
PKSH032584-50ug50ug£553.00
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This product comes from: China.
Typical lead time: 14-21 working days.
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Further Information

Abbreviation:
IDO1;IDO
Accession:
P14902
Activity:
Measured by its ability to oxidize L-tryptophan to N-formyl-kynurenine. The specific activity is 5166. 667 pmol/min/ug pmol/min/ug.
Background:
Indoleamine 2,3-dioxygenase (IDO) is a heme enzyme that initiates the oxidative degradation of the least abundant, essential amino acid, l-tryptophan, along the kynurenine pathway. This protein is normally expressed in the dendritic cells, macrophages, microglia, eosinophils, fibroblasts, endothelial cells, and most tumor cells. IDO activity is associated with immunosuppression and immune attenuation. Several studies showed that IDO can contribute to immune escape when expressed directly in tumor cells or when expressed in immunosuppressive antigen presenting cells such as tolerogenic dendritic cells or tumor associated macrophages. IDO also is a promising therapeutic target for the treatment of cancer, chronic viral infections, and other diseases characterized by pathological immune suppression.
Calculated MW:
46.8 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
E.coli
Formulation:
Supplied as a 0.2 um filtered solution of 20mM Sodium Acetate, 150mM NaCl and 20% Glycerol, pH4.5.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
N-6His
ObservedMW:
40-50 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Met 1-Gly403
Target Synonym:
Indole 2;3-dioxygenase;Indoleamine 2;3-dioxygenase 1;IDO-1;IDO1;IDO;INDO
UNIProt ID:
P14902

Documents