Elabscience

Recombinant Human PD-1/PDCD1 Protein (His Tag)(Active)

Product Code:
 
PKSH031642
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Application:
 
Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Samples are stable for up to twelve months from date of receipt at -70°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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CodeSizePrice
PKSH031642-100ug100ug£664.00
Quantity:
PKSH031642-1mg1mg£4,607.00
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This product comes from: China.
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Further Information

Abbreviation:
PD-1;PDCD1
Accession:
NP_005009.2
Activity:
Immobilized human PD-1 at 10 ug/ml (100 ul/well) can bind recombinant human B7-H1 / PD-L1 / Fc chimera with a linear range of 0.02-0.4 ug/ml.
Background:
Programmed cell death 1; also known as PDCD1; is a type I transmembrane glycoprotein; and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase; SHP-2 upon interacting with either of two ligands; PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1; IL-4; IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition; coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance; and thus contributes to the prevention of autoimmune diseases. Furthermore; PD1 is shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection. As a cell surface molecule; PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation; cytokine production; and cytolytic function.
Calculated MW:
17.4 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-His
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Met 1-Gln 167
Target Synonym:
Programmed cell death protein 1;PDCD1;PD-1;hPD-1;CD279;SLEB2;Hsle1

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