Recombinant Human PGD2 Synthase/PTGDS Protein (His Tag)

PGD2 Synthase;PTGDS

P41222

Prostaglandin-H2 D-Isomerase (PTGDS) belongs to the Lipocalin family of calycin superfamily. PTGDS is preferentially expressed in the brain. PTGDS catalyzes the conversion of PGH2 to PGD2; a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. PTGDS is involved in a variety of CNS functions; such as sedation; REM sleep and PGE2-induced allodynia; and may have an anti-apoptotic role in oligodendrocytes. PTGDS binds small non-substrate lipophilic molecules and may act as a scavenger for harmful hydrophopic molecules and a secretory retinoid and thyroid hormone transporter. It possibly participates in development and maintenance of the blood-brain; blood-retina; blood-aqueous humor; blood-testis barrier; the central nervous system and male reproductive system.

19.7 kDa

< 1.0 EU per ug of the protein as determined by the LAL method.

HEK293 Cells

Supplied as a 0.2 um filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH7.5.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

C-6His

20-27 kDa

> 95 % as determined by reducing SDS-PAGE.

Ala23-Gln190

Prostaglandin D Synthase;Prostaglandin-H2 D-Isomerase;Beta-Trace Protein;Cerebrin-28;Glutathione-Independent PGD Synthase;Lipocalin-Type Prostaglandin-D Synthase;Prostaglandin-D2 Synthase;PGD2 Synthase;PGDS;PGDS2;PTGDS;PDS

P41222