Elabscience

Phospho-GSK3 beta (Ser9) Polyclonal Antibody

Product Code:
 
E-AB-20886
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
-20°C
1 / 2
Immunohistochemistry of paraffin-embedded Human colon tissue using Phospho-GSK3 beta (Ser9) Polyclonal Antibody at dilution of 1:200
2 / 2
Immunofluorescence analysis of Rat spleen tissue using Phospho-GSK3 beta (Ser9) Polyclonal Antibody at dilution of 1:200
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Immunohistochemistry of paraffin-embedded Human colon tissue using Phospho-GSK3 beta (Ser9) Polyclonal Antibody at dilution of 1:200
Immunofluorescence analysis of Rat spleen tissue using Phospho-GSK3 beta (Ser9) Polyclonal Antibody at dilution of 1:200

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E-AB-20886-20uL20uL£125.00
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E-AB-20886-120uL120uL£237.00
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E-AB-20886-200uL200uL£344.00
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  • Further Information
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Further Information

Abbreviation:
GSK3β (phospho Ser9)
Background:
Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair.
Buffer:
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Calculated MW:
47kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:100-1:300, ELISA 1:5000-1:20000
Immunogen:
Synthesized peptide derived from human GSK3β around the phosphorylation site of Ser9
ObservedMW:
48kDa
Purification method:
Affinity purification
Target Synonym:
Glycogen Synthase Kinase 3 Beta;Glycogen synthase kinase-3 beta;GSK 3 beta;GSK-3 beta;GSK3B;GSK3B;GSK3beta isoform;Serine/threonine-protein kinase GSK3B
UNIProt ID:
P49841

Documents

References

  • https://www.sciencedirect.com/science/article/pii/S0891584920312764
  • https://www.frontiersin.org/articles/10.3389/fphys.2017.00510/full
  • https://www.karger.com/Article/Abstract/452571
  • https://www.sciencedirect.com/science/article/pii/S0753332217330597