FZD6 Polyclonal Antibody

FZD6

This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

0.2 mg/mL

Unconjugated

IHC 1:100-1:300

Synthetic peptide of human FZD6

Affinity purification

Frizzled 6 seven transmembrane spanning receptor;Frizzled drosophila homolog of 6;Frizzled family receptor 6;Frizzled homolog 6 (Drosophila);Frizzled homolog 6;Frizzled-6;Frizzled6;Fz 6;Fz-6;Fz6;FZD 6;Fzd6;FZD6;Hfz 6;hFz6;NDNC10

O60353