Elabscience

Cleaved-CASP3 p12 (D175) Polyclonal Antibody

Product Code:
 
E-AB-30003
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
-20°C
1 / 2
Western Blot analysis of KB cells using Cleaved-CASP3 p12 (D175) Polyclonal Antibody at dilution of 1:1000.
2 / 2
Immunofluorescence analysis of Human liver cancer tissue using Cleaved-CASP3 p12 (D175) Polyclonal Antibody at dilution of 1:200.
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Western Blot analysis of KB cells using Cleaved-CASP3 p12 (D175) Polyclonal Antibody at dilution of 1:1000.
Immunofluorescence analysis of Human liver cancer tissue using Cleaved-CASP3 p12 (D175) Polyclonal Antibody at dilution of 1:200.

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  • Further Information
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Further Information

Abbreviation:
Cleaved-Caspase-3 p12 (D175)
Background:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
Buffer:
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Calculated MW:
32kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-2000, IHC 1:50-300, IF 1:50-300
Immunogen:
Synthesized peptide derived from the Internal region of human Caspase-3 p12
ObservedMW:
20+35kDa
Purification method:
Affinity purification
Target Synonym:
A830040C14Rik;Apopain;CASP-3;CASP3;CASP3;Casp3a;Caspase 3;Caspase 3;apoptosis-related cysteine peptidase;Caspase 3;apoptosis-related cysteine protease;Caspase 3;apoptosis-related cysteine protease a;Caspase-3 subunit p12;CC3;CPP-32;CPP32;CPP32B;Cysteine protease CPP32;EC 3.4.22.56;LICE;mldy;OTTHUMP00000165052;OTTHUMP00000165053;OTTHUMP00000165054;PARP cleavage protease;Procaspase3;Protein Yama;SCA 1;SCA-1;SREBP cleavage activity 1;Yama
UNIProt ID:
P42574

Documents

References

  • https://www.nature.com/articles/s41590-022-01166-6
  • https://static.frontiersin.org/articles/10.3389/fmolb.2022.816510/full
  • https://www.frontiersin.org/articles/10.3389/fphar.2021.646953/full?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FPHAR_XXXXXXXX_auto-dlvrit
  • https://www.worldscientific.com/doi/abs/10.1142/S0192415X21500245
  • https://www.sciencedirect.com/science/article/pii/S094471131630191X