Elabscience

RANKL Polyclonal Antibody

Product Code:
 
E-AB-68352
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunofluorescence (IF)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Western blot analysis of extracts of various cell lines using RANKL Polyclonal Antibody at 1:1000 dilution.
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Western blot analysis of extracts of various cell lines using RANKL Polyclonal Antibody at 1:1000 dilution.

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CodeSizePrice
E-AB-68352-60uL60uL£210.00
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E-AB-68352-120uL120uL£291.00
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E-AB-68352-200uL200uL£431.00
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This product comes from: China.
Typical lead time: 14-21 working days.
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Further Information

Abbreviation:
RANKL
Background:
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
Buffer:
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Calculated MW:
27kDa/30kDa/35kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000,IF 1:50-1:200
Immunogen:
Recombinant fusion protein of human RANKL
ObservedMW:
31KDa/45KDa
Purification method:
Affinity purification
Target Synonym:
TNFSF11;CD254;ODF;OPGL;OPTB2;RANKL;TNLG6B;TRANCE;hRANKL2;sOdf
UNIProt ID:
O14788

Documents