Elabscience

HLA-DRB4 Polyclonal Antibody

Product Code:
 
E-AB-90065
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze/thaw cycles.
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Western blot analysis of extracts of various cell lines using HLA-DRB4 Polyclonal Antibody at 1:1000 dilution.
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Western blot analysis of extracts of various cell lines using HLA-DRB4 Polyclonal Antibody at 1:1000 dilution.

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E-AB-90065-60uL60uL£210.00
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E-AB-90065-120uL120uL£291.00
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E-AB-90065-200uL200uL£431.00
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This product comes from: China.
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Further Information

Abbreviation:
HLA-DRB4
Background:
HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Buffer:
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Calculated MW:
29kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:1000-1:4000
Immunogen:
Recombinant fusion protein of human HLA-DRB4
ObservedMW:
29kDa
Purification method:
Affinity purification
Target Synonym:
HLA-DRB4;DR4;DRB4;HLA-DR4B;major histocompatibility complex;class II;DR beta 4
UNIProt ID:
P13762

Documents