Elabscience

FICD Polyclonal Antibody

Product Code:
 
E-AB-90665
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze/thaw cycles.
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Western blot analysis of extracts of various cell lines using FICD Polyclonal Antibody at 1:3000 dilution.
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Western blot analysis of extracts of various cell lines using FICD Polyclonal Antibody at 1:3000 dilution.

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CodeSizePrice
E-AB-90665-60uL60uL£210.00
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E-AB-90665-120uL120uL£291.00
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E-AB-90665-200uL200uL£431.00
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This product comes from: China.
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Further Information

Abbreviation:
FICD
Background:
Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP to specific residues of target proteins (AMPylation, and the removal of the same modification from target proteins (de-AMPylation, depending on the context (By similarity. The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase will take place (By similarity. Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR by mediating AMPylation or de-AMPylation of HSPA5/BiP. In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it (By similarity. In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity (By similarity. Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates.
Buffer:
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Calculated MW:
51kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000
Immunogen:
Recombinant fusion protein of human FICD
ObservedMW:
51kDa
Purification method:
Affinity purification
Target Synonym:
FICD;HIP13;HYPE;UNQ3041
UNIProt ID:
Q9BVA6

Documents