Elabscience

Recombinant Human B7-H4/VTCN1 Protein (aa 29-258, His Tag)

Product Code:
 
PDMH100005
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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CodeSizePrice
PDMH100005-20ug20ug£178.00
Quantity:
PDMH100005-100ug100ug£237.00
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This product comes from: China.
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Further Information

Abbreviation:
B7-H4;VTCN1
Accession:
Q7Z7D3
Background:
V-set domain-containing T-cell activation inhibitor 1; also known as B7X; B7H4; B7S1; and VTCN1; is a single-pass type membrane protein belonging to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. They provide costimulatory signals that regulate T cell responses. A soluble form of B7H4 has also been detected. B7X / VTCN1 / B7H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation; proliferation; cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages; B7X / VTCN1 / B7H4 plays an important role; together with regulatory T-cells(Treg); in the suppression of tumor-associated antigen-specific T-cell immunity. B7X / VTCN1 / B7H4 is also involved in promoting epithelial cell transformation. This membrane protein can be up-regulated by IL6 / interleukin-6 and IL10 / interleukin-10 and inhibited by CSF2 / GM-CSF and IL4 / interleukin-4 on antigen-presenting cells.
Calculated MW:
26.8 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-His
ObservedMW:
43-48 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Phe29-Ala258
Target Synonym:
B7S1;B7x;Vtcn1;B7h.5;B7-H4;B7H4T-cell costimulatory molecule B7x;B7S1VCTN1;B7XPRO1291;FLJ22418;Immune costimulatory protein B7-H4;Protein B7S1;T cell costimulatory molecule B7x;V-set domain containing T cell activation inhibitor 1;V-set domain-containing T-cell activation inhibitor 1
UNIProt ID:
Q7Z7D3

Documents