Recombinant Human Insulin Receptor/INSR Protein (His & GST Tag)(Active)
Shipping:
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt store it immediately at < -20°C.
Storage:
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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This product comes from:
China.
Typical lead time:
14-21 working days.
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Further Information
Insulin Receptor;INSR
NP_000199.2
The specific activity was determined to be 45 nmol/min/mg using Poly(Ala, Glu, Lys, Tyr)6:2:5:1 as substrate.
INSR (Insulin receptor), also known as CD220, is a transmembrane receptor that is activated by insulin. INSR belongs to theprotein kinase superfamily, and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding to insulin, including IRS1 (insulin receptor substrate 1) and phosphatidylinositol 3'-kinase (PI3K). IRS-1 binding and phosphorylation eventually leads to an increase in the high affinity glucose transporter (Glut4) molecules on the outer membrane of insulin-responsive tissues. INSR isoform long and isoform short are expressed in the peripheral nerve, kidney, liver, striated muscle, fibroblasts and skin, and is found as a hybrid receptor with IGF1R which also binds IGF1 in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibrobasts, spleen and placenta. Defects in Insulin Receptor/INSR are the cause of Rabson-Mendenhall syndrome (Mendenhall syndrome), insulin resistance (Ins resistance), leprechaunism (Donohue syndrome), and familial hyperinsulinemic hypoglycemia 5 (HHF5). It may also be associated with noninsulin-dependent diabetes mellitus (NIDDM).
72.3 kDa
< 1.0 EU per ug of the protein as determined by the LAL method.
Baculovirus-Insect Cells
Supplied as sterile 50mM Tris, 100mM NaCI, pH 7.5, 25% glycerol, 1mM TCEP,0.5mM GSH
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
N-His & GST
70 kDa
> 92 % as determined by reducing SDS-PAGE.
Gly 989-Ser 1382
CD220;HHF5;Insulin Receptor