Elabscience

Recombinant Human CD300a/LMIR1 Protein (Fc Tag)

Product Code:
 
PKSH030836
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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This product comes from: China.
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Further Information

Abbreviation:
CD300a;LMIR1
Accession:
Q9UGN4-1
Background:
CMRF35-like molecule 8; also known as CD300 antigen-like family member A; CMRF35-H9; Immunoglobulin superfamily member 12; Inhibitory receptor protein 60; NK inhibitory receptor; CD300a and CMRF35H; is a single-pass type I membrane protein which belongs to theCD300 family. The CD300 family of myeloid immunoglobulin receptors includes activating ( CD300b; CD300e ) and inhibitory members ( CD300a; CD300f ); as well as molecules presenting a negative charge within their transmembrane domain ( CD300c; CD300d ). CD300A / IGSF12 is expressed not only by natural killer (NK) cells but also by T-cell subsets; B-cells; dendritic cells; mast cells; granulocytes and monocytes.It contains oneIg-like V-type ( immunoglobulin-like ) domain. CD300A / IGSF12 is an inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells; and to the down-regulation of mast cell degranulation. CD300c is a functional immune receptor able to deliver activating signals upon ligation in RBL-2H3 mast cells. CD300c signaling is partially mediated by a direct association with the immune receptor tyrosine-based activation motif-bearing adaptor FcεRγ. CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from plasmacytoid dendritic cells (pDCs).
Calculated MW:
44.5 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-hFc
ObservedMW:
58-66 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Met 1-Gln178
Target Synonym:
CMRF35-Like Molecule 8;CLM-8;CD300 Antigen-Like Family Member A;CMRF-35-H9;CMRF35-H9;CMRF35-H;IRC1/IRC2;Immunoglobulin Superfamily Member 12;IgSF12;Inhibitory Receptor Protein 60;IRp60;NK Inhibitory Receptor;CD300a;CD300A;CMRF35H;IGSF12
UNIProt ID:
Q9UGN4

Documents