Elabscience

Recombinant Human Fumarase/FH Protein (His Tag)(Active)

Product Code:
 
PKSH030901
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
 

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PKSH030901-100ug100ug£566.00
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This product comes from: China.
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Further Information

Abbreviation:
Fumarase;FH
Accession:
P07954-1
Activity:
Measured by its ability to transform 1umole of Fumarate to L-malate per minute at pH 7.5 at 37°C. Specific activity is > 25 unit/mg.
Background:
Fumarate Hydratase (FH) is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. Fumarate Hydratase is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. Individuals with hemizygous germline fumarate hydratase (FH) mutations are predisposed to renal cancer. These tumors predominantly exhibit functional inactivation of the remaining wild-type allele, implicating FH inactivation as a tumor-promoting event.
Calculated MW:
52 kDa
Expression Host:
E.coli
Formulation:
Lyophilized from sterile 10mM Tris, 5mM EDTA, 1mM DTT, pH 7.5
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-His
ObservedMW:
45 kDa
Purity:
> 85 % as determined by reducing SDS-PAGE.
Sequence:
Ala 45-Lys 510
Target Synonym:
Fumarate Hydratase Mitochondrial;Fumarase;FH;FMRD;HLRCC;LRCC;MCL;MCUL1
UNIProt ID:
P07954

Documents