Elabscience

Recombinant Human ICOS Ligand/ICOSL Protein (His Tag)(Active)

Product Code:
 
PKSH031085
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Application:
 
Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
 

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PKSH031085-100ug100ug£467.00
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This product comes from: China.
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Further Information

Abbreviation:
ICOS Ligand;ICOSL
Accession:
NP_056074.1
Activity:
Immobilized human B7-H2 at 1 ug/ml (100 ul/well) can bind human ICOS with a linear range of 1. 6-200 ng/ml.
Background:
Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.
Calculated MW:
28 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-His
ObservedMW:
50-60 kDa
Purity:
> 98 % as determined by reducing SDS-PAGE.
Sequence:
Met 1-Ser 258
Target Synonym:
ICOS Ligand;B7 Homolog 2;B7-H2;B7-Like Protein Gl50;B7-Related Protein 1;B7RP-1;CD275;ICOSLG;B7H2;B7RP1;ICOSL;KIAA0653

Documents