Elabscience

Recombinant Human FLRT2 Protein (His Tag)(Active)

Product Code:
 
PKSH031164
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Applications:
  • Cell Culture
  • Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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This product comes from: China.
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Further Information

Abbreviation:
FLRT2
Accession:
O43155
Activity:
Measured by the ability of the immobilized protein to support the adhesion of Neuro-2A mouse neuroblastoma cells. When cells are added to coated plates(5ug/mL, 100uL/well), approximately 50%-70% will adhere after 1 hour at 37°C.
Background:
Fibronectin Leucine-Rich Transmembrane (FLRT) proteins are glycosylated membrane proteins expressed at the cell surface which localise in a homophilic manner to cell-cell contacts expressing the focal adhesion marker vinculin. FLRT1; FLRT2; and FLRT3; the three genes encode putative type I transmembrane proteins; each containing 10 leucine-rich repeats (LRR); a type III fibronectin (FN) domain; followed by the transmembrane region; and a short cytoplasmic tail. FLRT family members may function in cell adhesion and/or receptor signalling. Each member of the FLRT family has a distinct; highly regulated expression pattern; as was seen for the NLRR family. FLRT2 is expressed in a subset of the sclerotome; adjacent to the region that forms the syndetome; suggesting that interaction with FGF signalling may be a general property of FLRT proteins. All FLRTs can interact with FGFR1 and FLRTs can be induced by the activation of FGF signalling by FGF-2. FLRT proteins have a dual role; promoting FGF signalling and modulating homotypic cell adhesion. FLRT2 played critical roles in craniofacial development; and it was also present in the vomero-nasal organ; mandibular primodia; and the posterior aspects of the unfused and fused secondary palatal shelves.
Calculated MW:
57.7 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-His
Purity:
> 98 % as determined by reducing SDS-PAGE.
Sequence:
Met 1-Ser 539
Target Synonym:
Leucine-Rich Repeat Transmembrane Protein FLRT2;Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 2;FLRT2;KIAA0405
UNIProt ID:
O43155

Documents