Elabscience

Recombinant Human HER3/ErbB3 Protein (aa 730-1065, His &GST Tag)(Active)

Product Code:
 
PKSH031765
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Application:
 
Bio-Layer Interferometry
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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PKSH031765-50ug50ug£832.00
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Further Information

Abbreviation:
HER3;ErbB3
Accession:
NP_001973.2
Activity:
1. No Kinase Activity 2. Using the Octet RED System, the affinity constant (Kd) of human ErBB3-GST bound to human NRG1 (aa 2-224) was 20 nM.
Background:
ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
Calculated MW:
65 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
Baculovirus-Insect Cells
Formulation:
Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 7.5, 10% glycerol, 1mM GSH
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
N-His-GST
ObservedMW:
65 kDa
Purity:
> 75 % as determined by reducing SDS-PAGE.
Sequence:
Pro 730-Ser 1065
Target Synonym:
c-erbB-3;c-erbB3;EEBB3;ErbB-3;erbB3-S;HER3;LCCS2;MDA-BF-1;p180-ErbB3;p45-sErbB3;p85-sErbB3

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