Elabscience

Recombinant Human IL1RL1/ST2 Protein (Fc Tag)(Active)

Product Code:
 
PKSH031875
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Application:
 
Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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PKSH031875-100ug100ug£467.00
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This product comes from: China.
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Further Information

Abbreviation:
IL1RL1;ST2
Accession:
NP_003847.2
Activity:
Immobilized human IL-33 at 10 ug/ml (100 ul/well) can bind human IL1RL1 / Fc Chimera with a linear range of 0.31-5 ng/ml.
Background:
IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines.
Calculated MW:
67.1 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-hFc
ObservedMW:
85-95 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Met 1-Phe 328
Target Synonym:
DER4;FIT-1;IL1RL1;IL33R;IL-1 R4;ST2;ST2L;ST2V;T1

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