Elabscience

Recombinant Mouse REN1/Renin-1 Protein (His Tag)(Active)

Product Code:
 
PKSM040760
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Mouse
Regulatory Status:
 
RUO
Application:
 
Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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PKSM040760-50ug50ug£664.00
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This product comes from: China.
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Further Information

Abbreviation:
REN1;Renin-1
Accession:
NP_112469.1
Activity:
Measured by its ability to cleave the fluorogenic peptide substrate 5?FAM/QXL™ 520 (Peti?Peterdi, J. et al., 2009, Physiology 24:88.). The specific activity is > 20 pmoles/min/ug. 2. Immobilized mouse REN1-His at 10ug/ml (100 ul/well) can bind biotinylated human AGT-His with a linear range of 31. 25-250 ng/ml.
Background:
Renin-1, also known as Ren-1, Angiotensinogenase and Kidney renin, is a member of thepeptidase A1 family. Renin-1 is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. androgen and thyroid hormones influence levels of Renin-1 in mouse submandibular gland (SMG) primarily by regulating the amount of Renin-1 mRNA available for translation. Renin-1 is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. It is expressed at relatively low levels in mouse SMG and kidney. Ren-2 is expressed at high levels in the mouse SMG and at very low levels, if at all, in the kidney. Ren-1 and Ren-2 are closely linked on mouse chromosome 1, show extensive homology in coding and noncoding regions and provide a model for studying the regulation of gene expression.
Calculated MW:
43.2 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-His
ObservedMW:
48-55 kDa
Purity:
> 97 % as determined by reducing SDS-PAGE.
Sequence:
Met 1-Arg 402
Target Synonym:
Renin-1;Angiotensinogenase;Kidney renin;Ren1;Ren;Ren-1;Angiotensin-forming enzyme;Ren-A;Ren1c;Ren1d;Rn-1;Rnr

Documents