L1CAM Antibody / NCAM-L1 / CD171

ELISA (order BSA-free format for coating)

Optimal dilution of the L1CAM antibody should be determined by the researcher.

Recognizes a cell surface protein of 220-240kDa, identified as L1 cell adhesion molecule. The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, and adducted thumbs); and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, and neural migration as well as in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. This MAb is useful in the identification of primitive neuroectodermal tumors. It binds to tumors of neuroectodermal and glial origin e.g. neuroblastoma and Schwannomas. It does not bind to pediatric or adult brain.

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Homogenous suspension of 16-week human fetal brain cells were used as the immunogen for the L1CAM antibody.

This L1CAM antibody is available for research use only.

Cell Surface

Protein A/G affinity

P32004