Cyclin E1 Antibody / CCNE1

ELISA (order BSA-free format for coating)

Optimal dilution of the antibody should be determined by the researcher.

Cyclin E belongs to the highly conserved cyclin family, whose members exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Cyclin E overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

A recombinant human partial protein (amino acids 10-176) was used as the immunogen for this Cyclin E1 antibody.

This Cyclin E1 antibody is available for research use only.

Protein G affinity chromatography

P24864