NSJ Bioreagents

Bcl6 Antibody

Product Code:
 
NSJ-V3496SAF
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1 kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
BCL6/1527
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Immunohistochemistry- Paraffin Embedded (IHC-P)
Storage:
 
Store the Bcl6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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Protein array validation of the Bcl6 antibody: Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using Bcl6 antibody (clone BCL6/1527). These results demonstrate the foremost specificity of the BCL6/1527 mAb.<BR>Z- and S- score: The Z-score represents the strength of a
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Protein array validation of the Bcl6 antibody: Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using Bcl6 antibody (clone BCL6/1527). These results demonstrate the foremost specificity of the BCL6/1527 mAb.<BR>Z- and S- score: The Z-score represents the strength of a

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NSJ-V3496SAF-100UG100 ug£534.00
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Further Information

Application Details:
ELISA: 1-5ug/ml
Application Note:
Optimal dilution of the Bcl6 antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Description:
Antibody to Bcl-6 is helpful in a number of diagnostic settings: First, in the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show Bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. Second, Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, Bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. Third, Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (L&H) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
Format:
Purified
Formulation:
1 mg/ml in 1X PBS; BSA free, sodium azide free
Immunogen:
Amino acids 256-389 were used as the immunogen for the Bcl6 antibody.
Limitation:
This Bcl6 antibody is available for research use only.
Localization:
Nuclear
Purity:
Protein G affinity chromatography
Uniprot #:
P41182

Documents