NSJ Bioreagents

CD46 Antibody

Product Code:
 
NSJ-V2190SAF
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1 kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
122.2
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Fluorescence-activated cell sorting (FACS)
  • Functional Study
  • Immunofluorescence (IF)
Storage:
 
Store the CD46 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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FACS staining of human PBMC using CD46 antibody (clone 122.2).~
2 / 2
SDS-PAGE Analysis of Purified, BSA-Free CD46 Antibody (clone 122.2). Confirmation of Integrity and Purity of the Antibody.
❮❯

FACS staining of human PBMC using CD46 antibody (clone 122.2).~
SDS-PAGE Analysis of Purified, BSA-Free CD46 Antibody (clone 122.2). Confirmation of Integrity and Purity of the Antibody.

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NSJ-V2190SAF-100UG100 ug£534.00
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Further Information

Application Details:
Functional studies (order BSA/sodium azide-free format),Flow cytometry: 1-2ug/million cells,Immunofluorescence: 1-2ug/ml
Application Note:
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the CD46 antibody to be titered up or down for optimal performance.
Description:
CD46 acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
Format:
Purified
Formulation:
1 mg/ml in 1X PBS; BSA free, sodium azide free
Gene ID #:
4179
Immunogen:
Recombinant human protein was used as the immunogen for this CD46 antibody.
Limitation:
This CD46 antibody is available for research use only.
Localization:
Cell surface
Purity:
Protein G affinity chromatography

Documents