ELK Biotechnology

Recombinant Mouse B7-H4 (C-Fc)

Product Code:
 
ELK-EPT204
Product Group:
 
Recombinant Proteins
Supplier:
 
ELK Biotechnology
Host Type:
 
Mouse
Regulatory Status:
 
RUO
Shipping:
 
The product is shipped at ambient temperature.
Storage:
 
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
 

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CodeSizePrice
ELK-EPT204-10ug10ug£219.00
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This product comes from: China.
Typical lead time: 14-21 working days.
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Further Information

Accession:
AAH32925.1
Alternative Names:
V-set domain containing T-cell activation inhibitor 1; B7 homolog 4; Protein B7S1; B7-H4; VTCN1
Apparent Molecular Weight:
70-90 KDa, reducing conditions
Background:
Mouse V-set domain-containing T-cell activation inhibitor 1/VTCN1/B7-H4 is glycosylated member of the B7 family of immune co-stimulatory proteins. B7-H4 consists of extracellular domain (ECD) with one Ig-like V-set domain and one Ig-like C2-set domain. It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.
Biological Activity:
Immobilized Anti-Human B7-H4 mAb(Cat#NC054) at 2ug/ml (100 ul/well) can bind Mouse B7-H4-Fc*(Cat#CS04).*: Biotinylated by NHS-biotin prior to testing The ED50 of Mouse B7-H4-Fc*(Cat#CS04) is 4.11 ng/ml.
Endotoxin:
Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Molecular Weight:
52.2 KDa
Purity:
Greater than 95% as determined by reducing SDS-PAGE.
Redissolve:
Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100ug/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.?