TargetMol

GA-017

Product Code:
 
TAR-T60013
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T60013-1mg1mg£164.00
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TAR-T60013-5mg5mg£303.00
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TAR-T60013-1mL1 mL * 10 mM (in DMSO)£325.00
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TAR-T60013-10mg10mg£430.00
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TAR-T60013-25mg25mg£590.00
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TAR-T60013-50mg50mg£863.00
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Quantity:
TAR-T60013-100mg100mg£1,139.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
GA-017 is a potent and selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1/2), with IC 50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids [1].
CAS:
2351906-74-4
Molecular Weight:
343.38
Purity:
0.9882
SMILES:
O=C(NN=C(C1=CC=C(O)C(=C1O)C)CC)NCC=2C=CC=C(O)C2

Documents

References

Aihara A, et al. Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions. J Biol Chem. 2022 Apr;298(4):101779.