TargetMol

SHMT-IN-2

Product Code:
 
TAR-T62404
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T62404-1mg1mg£130.00
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TAR-T62404-5mg5mg£213.00
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Quantity:
TAR-T62404-1mL1 mL * 10 mM (in DMSO)£241.00
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TAR-T62404-10mg10mg£303.00
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TAR-T62404-25mg25mg£535.00
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TAR-T62404-50mg50mg£816.00
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Quantity:
TAR-T62404-100mg100mg£1,075.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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  • Further Information
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Further Information

Bioactivity:
SHMT-IN-2 (compound 2) is a specific human SHMT1/2 small molecule inhibitor that acts on SHMT1 (IC50: 13 nM) and SHMT2 (IC50: 66 nM). SHMT-IN-2 inhibits the growth of many human cancer cells and is sensitive to B-cell lymphoma.
CAS:
2102681-49-0
Molecular Weight:
431.45
Purity:
0.9845
SMILES:
N#CC1=C(OC2=NNC(=C2C1(C=3C=C(C=C(C3)C(F)(F)F)N4CCCC4)C(C)C)C)N

Documents

References

regory S Ducker, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.